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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

Someone might tell you to ‘Be yourself' in the interview. Don't be yourself. That's the worst advice ever. We don't want people who are neurotic and quirky and whatever else. All we care about is your skill and experience.
Qube会提醒你注意垃圾回收,在垃圾最后被倒出来的时候进行监控,并告诉你更换空气清新剂。但这些人们通常可以通过嗅觉和其他感觉器官来判断。现在有一个300美元的“优雅”不锈钢,会不断用讨人厌的移动警报提醒你。

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

adj. 在 ... 之前,先,前,以前的
周三,北京市市委宣布,计划将绝大部分的北京市政府部门在2017年迁至通州区。

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
From the themed collection: 南京过去3年 新房价格普涨万元
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

Both Samsung and BlackBerry quickly put the kibosh on a report Wednesday afternoon that the two are engaged in takeover talks. But why would the world’s biggest smartphone company pay a rumored $7.5 billion for a Canadian tech company whose glory days are past? Answer: Its rich intellectual property portfolio—especially all its juicy security innovations.

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

这只漂亮的伯曼猫在Ins上有超过128000名粉丝,而且它还是拉格菲尔德众多设计的灵感。

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
From the themed collection: 绿色智能制造成行业下一个风口
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

课程安排:周五周六交替上课,入学伊始学员需参加一个为期一周的会议,还有一个为期一周的国际学习研讨会
Life's ups and downs
5)我支持你:我们都犯过大错误。此时,不要回避,要对对方说一些肯定的话语:“我不是在说你不行。你会度过这个难关的。你不是一个人在战斗。我们将一起解决此事。一切都会没事的。”
Add your scores for 10 to 14 to find out how you score on the Social Inhibition scale.

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

但是我们波士士顿波士顿咨询集团不认为中国本次改革会导致中国经济不稳定。我们相信中国经济在习主席的领导下会持续高速增长。我们相信上个星期的改革(三中全会)会确保中国经济从现在一直增长到(至少)2020年。根据我们已掌握的资料,我们预测中国经济在未来10年会增加4万亿美金(而书中说是6.4万亿。2012中国GDP为8.3万亿美金)。如果加上印度,亚洲两大国未来的增长总量会达到10万亿美金。在此期间,中产阶级会迅速膨胀,进而增强对经济增长的乐观态度。当然,没有人能完美地预测未来,在我们的近期的一本关于中国和印度经济发展的书中(《Trillion Prize:Captivating the Newly Affluent in China and India》),我们也描述了一些经济增长缓慢的例子。不过总体上我们还是对中国的未来保持乐观态度。
Star Wars: Rogue One is set to release on December 16, 2016.
The stomach-churning finding is not the first to be exposed in the area. Police in Guangxi, along China's border with Vietnam, have stepped up anti-smuggling operations over the last year and have raided seven illegal food processors.
A panel of eight WardsAuto editors evaluated 44 engines among all vehicle types during October and November in the course of their daily commutes and weekend activities in and around the Detroit metro area. Engines were rated according to a wide range of characteristics including horsepower and torque, fuel economy, noise, vibration and harshness characteristics, technology and how they fared against competing powerplants.

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

Here are the 10 winners of the 2012 Ig Nobel Prizes given to scientists, writers, and peacemakers who make silly but thoughtful contributions to the world, or as the Annals of Improbable Research puts it, "first make people laugh, and then make them think." I can vouch for them making us laugh!

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

Confidence and a good elevator speech can take any pitch to the next level. The first marketing any company experiences comes from its founder. Spend time learning how to share your vision without coming across as “salesy.” Don’t be afraid to ask for the sale, but remember: the client is always the focus.

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
From the themed collection: 解析LED行业“钱景”大趋势
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

Founded in the 5th century and covering 118 small islands, the Northeast Italian city is famed for its water views, architecture and artwork.
Uruguay represents a more curious case, in that its players are footballing aristocracy disguised as minnows. Like Belgium, it is a relatively young nation, yet on the field of play the Uruguayans are old hands. They have won the World Cup twice, first at the inaugural event in 1930, and then in 1950, when Brazil hosted the tournament. The latter occasion, when Brazil succumbed in front of a world-record 200,000 fans or more, is referred to there as the "Maracanazo", a national tragedy still felt today.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
From the themed collection: 2020年我国智慧社区将达五成
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

temptation
bent

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

就像你不需要一个智能开瓶器一样,你同样不需要一个智能酒瓶。kuvee是一个有屏幕的酒瓶,它可以帮助您了解您最喜爱的葡萄酒。除了它还能为你的葡萄酒保鲜30天,其余也没别的什么功能。
but the rate of growth appeared to slow noticeably in a number of top cities.

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

As well as diversity, Mr Cook has championed sustainability and supply-chain transparency, including a commitment to reducing Apple’s use of conflict minerals. While hyper-efficient under Mr Cook’s management before he became chief executive, Apple’s supply chain has not always been something to boast about, with recurring complaints about working conditions.
Barrymore's condition was based on the real life of Michelle Philpots, who suffered head trauma in two separate motor vehicle accidents, which left her with a 24-hour memory. Rather than using Sandler's tapes, Philpots has survived for over 23 years using Post-it notes and her (amazingly modern, from her perspective) mobile phone.
Elsewhere, Stockholm School of Economics was a big winner, climbing 16 places to 28, not only recording the best year-on-year progression but also recovering from a drop of 11 places last year.
As for his own education: He's weighing whether to enroll in university in England or maybe the U.S. to be closer to Silicon Valley. Or perhaps he'll skip college entirely and just focus on his work. 'I absolutely want to start another company,' he says. 'Serial entrepreneurs get addicted to creation. I want to be passionate. I feel really bad when I'm not doing something new.'

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
From the themed collection: 2015淋浴房十大品牌最新排行榜
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

卡尔说:“如果要打赌的话,我赌今年比去年更热。”

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

人的身体是十分脆弱的,有些娇弱的器官一旦破坏就永远难以复原。幸运的是,世界各地的研究人员都在研究能替代我们身体部位的生化机械器官。
Libby把这首歌放在了YouTube频道的评论部分,我把它摘过来了。我将大量的可爱的表述和英式的俚语都用不同颜色区分开了。你能猜出其中的意思吗?“OMG”表带什么意思?

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

The pace of Japanese production rose at a brisk clip during the month of October, giving policymakers hope - if not more mixed messages - about the strength of the Japanese economy.

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

receptive

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

那些服装能引起共鸣,是因为身穿那些服装的剧中人物精致复杂,而不只是因为琼的织锦紧身连衣裙真的魅力四射,或者梅根的迷幻雪纺连衣裙让璞琪看起来很酷。
Meanwhile, figures such as Wang Jianlin, China’s richest man, have raised concerns about Chinese state-owned enterprises’ investments in Europe, arguing that they lack international management standards.
ScreamRide
In being named CEO, Mary Barra broke through several historical barriers in moving from GM's third-most powerful executive position to its first. Her job was made both easier by the appointment of a non-executive chairman to handle the board of directors, and more difficult by the decision to give her old job to one of her rivals. As the first product engineer to head the company in two decades, she will be deluged with suggestions about everything from air conditioning vents in new pickups to the future of brands like Buick and Chevrolet.

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

这位曾演唱过《Royals》(《皇室贵族》)的少年天才在20岁的时候就在联合制作人杰克·安东诺夫的帮助下更上一层楼,把对电子音乐的无限展望与人类的尺度结合在一起,亲手打造了自己的第二张专辑。
4、慧眼识香。邦德眼光敏锐,能辨认出孰敌孰友。这种品质常见于性开放者。007很容易识出对他有意的女人,有科学证明,帅哥往往擅长于此。
Awards: Despite early wins for VW’s Golf GTI, the Detroit-centric jurors of the North American Car and Truck award 2015 prizes to Ford’s Mustang as well as Ford’s F-150 pickup truck.
凸起那部分有个“涡卷饰品”——(古埃及碑上)在王和神的名字周围的椭圆形装饰。考古学家在上面发现有眼镜蛇一只眼的符号。
Since merged airlines often continue to report delay statistics separately, it may take a few years to see how the new American does during holiday travel.

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

10、日本8.5级地震
在《星球大战:原力觉醒》后,迪士尼影业和卢卡斯影业承诺每年冬天推出一部星球大战系列电影,都将围绕原来的主题展开。

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

Nothing else matters, not even basic astronomy.

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

蓝天和空气一样,对每个人都是平等的。

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

According to Putin's most recent income declaration, he earned roughly 8.9 million rubles ($137,000) in 2015.
Halloween is just a few days away. Which means, if you haven’t gotten your costume or decorations sorted out yet, you might want to start doing that pretty soon.
pne以前+vi路[引申为走]+ous→以前走过的→以前的
Industry Kitchen是位于纽约市南街海港的一间餐厅,你可以在这里购买到这款24K黄金比萨,其售价高达2000美元。顾名思义,黄金披萨因为覆盖了24k黄金金片而闻名。

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

Effective bosses and managers tend to:
"Hong Kong is a small island with 7 million people ... and you have 1.5 billion across the border (in mainland China) who would like to invest," Mark Elliott, associate director of International Residential Property Services at Jones Lang LaSalle, tells CNN. "The government is releasing more and more land, but it doesn't work."
上海复旦大学社会发展与公共政策学院院长彭希哲周二告诉环球时报,在产业结构升级的过程中,劳动密集型产业搬离都市圈,是导致这一人口变迁的最主要原因之一。
今年年底10年期美国国债收益率会突破3%吗?

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

A total of 2.81 million people who graduated in 2017, 2015 and 2013 from hundreds of Chinese universities were involved in the survey.
与此同时,最近几个月,中国内地投资者一直在迅速开设股票交易账户并将资金投入股市。上证综指已成为亚洲今年表现最佳的股指,今年迄今已累计上涨近45%。

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

韩国最大的整形医院之一,由权株创立的JK整形手术中心,近期开了一家旅馆来更好地服务顾客。这些顾客每次看病人均花费17675美元。
沃尔玛美国公司总裁兼首席执行官比尔西蒙
STEP 1: GET THE LOOK
你知道什么叫“深藏不露”吗?
私人侦探已进行指控,但是他们表示,不会公布枪击详情,除非两名年轻人周五出庭。

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

调查显示,2017年应届毕业生的就业意向仍然以就业为主,占比为73.5%。相较去年,选择在国内继续学习的学生比例出现大幅下降,由2016年的16.5%下降至今年的6.3%。
Since then, Teach First has put 5,000 graduates into schools, working with more than 1m pupils in low-income areas, helping to raise standards in classrooms, particularly London.
After the success of The Conjuring, Ed Warren and Lorraine Warren are back to kick some ghost butts. Conjuring 2 is based on the Enfield Poltergeist, which is apparently a true event that took place in London in 1977.

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
From the themed collection: 智能家居开放与标准化倡议出台
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

Were you late to work yesterday because you couldn't remember where you put your car keys? Did you completely forget about a coffee date last week with a friend and only remember when you got a text asking, "where are you?" Can you no longer remember the name of your favorite elementary school teacher? Memory problems impact just about everyone to a certain degree, but science suggests you might be able to improve your memory, as well as reduce the likelihood of Alzheimer's and dementia, by engaging in certain activities, eating specific foods, and using certain mnemonic devices.
Lawyers are inherently cautious but most have realised that technology is crucial to crunching through the vast amount of information they handle. Without it, certain document heavy processes, such as disclosure and compliance, would be nearly impossible.

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
From the themed collection: 中国建材行业一周大事记(7.20-7.26)
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

What would he try for his solo move: "Sweet Creature" and "Ever Since New York" are intimate acoustic ballads; while "Kiwi" lets him strut his Oasis-style self at top volume. "Two Ghosts" is a break-up lament .
D'ALOISIO HAS BEEN quoted opining that 'time is the new currency.' It's the driving notion behind Summly. It's also a strangely wise observation from a 17-year-old. At that age, many of us had more time on our hands than we knew how to fill without plummeting into severe boredom. It's easy to forget-conversing over lunch in a London caf钼 or strolling through the Tate Modern-that D'Aloisio was born in 1995 and has not yet graduated from high school. Or that he still lives in his childhood bedroom, in a cozy upper-middle-class home. As I chat with his parents, he excuses himself to work on his computer. Slouching down the hall in his stocking feet, hems of his skinny jeans brushing the hallway carpet, it is the most kidlike you will ever see him.
adj. 创造性的

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

The report didn't comment on potential factors influencing the numbers, but many – including members of the opposing political party – are laying the blame squarely at the feet of government cost-cutting.
通用汽车公司(General Motors)帮助改善了大峡谷州的就业前景。今年3月,这家汽车制造商宣布,计划在凤凰城郊区钱德勒建设该公司的第四座信息技术创新中心。通用汽车预计将雇佣1,000名员工,主要包括为这座新中心效力的软件开发人员、数据库管理员和系统分析师。通用汽车公司首席信息官兰迪?莫特(Randy Mott)在新闻稿中宣布了这个举措,他表示,“大凤凰城地区是出色的枢纽,吸引了新兴技术人才——从大学毕业生到职场专业人士。”
难怪各银行开始变得有创造力。

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

Other notable ladies who made the list include Kate Upton (No. 8), Taylor Swift (No. 12), Kim Kardashian (No. 38), and Sofia Vergara (No. 100.)

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

It's impossible to list every woman who's ever existed, this list obviously be restricted to women who've achieved a fair level of celebrity. These are the hottest women celebrities of 2015.

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

劳伦斯2016年的收入比2015年(5200万美元)减少了11.5%。本周四福布斯杂志还将发布2016年收入最高的男星排行榜。去年荣膺榜首的是小罗伯特-唐尼,收入约为8000万美元。
我立刻赞同了克雷格和尼尔关于艾伦是今年颁奖礼最合适的主持的想法。我们希望举办一场娱乐、吸引人而又有趣的颁奖礼。

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

图表二显示的是实际联邦基金利率(计入通胀因素后)和实际自然利率。可以再次看到,当联邦基金利率高于自然利率时,新兴市场危机更为常见。
Most successful entrepreneurs follow comparable patterns and share similar basic characteristics. Hundreds of online articles and published books claim to know the secret of success in business, but for the most part, they boil down to the same major points.
在家里创造一个属于自己的学习空间。如果身边家人都在身边,你就要确保大家都明白你是在里面学习,除非房子着火,他们是不会打扰到你的。
[d?ɑ:]

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

我是否玩儿得太high了?缺乏实现某些事情的动机会让你失去平衡或者稍后会让你感到筋疲力尽,很有压力。休息一下是非常有必要的,但是如果你休息得过了头从而使生产力降低,或者你养成了太过拖拉的习惯,那么或许就需要时间来平衡你的时间安排,以便你可以完成大量的事情而仍有时间休息娱乐。
You are the one for me this New Year and for many New Years to come.在此新年和未来的每个新年里,你都是我唯一的爱!

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

自动驾驶汽车:研究人员正在研究能让汽车自动倒车入库的设备,让你甚至不必坐在车里就能完成倒车。这样你就不必在不小心刮蹭到别人的车时,往人家的雨刮器下面留张字条,并附上你的电话号码了。
今年最引人注目的化妆和发型设计几乎都源自角色的原型本身(其中有些无疑比银幕上的造型更有活力)。除了能让观众一眼看出角色的外貌特征,它们也能为演员的表演赋予整体感觉和微妙之感。有时,一个大鼻子就能加深观众的理解。

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
From the themed collection: 家居卖场开春首个“促销季”来临
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

You’re a busy person. At times, it all can feel overwhelming. Asana is a cloud-based project management software that helps you keep it together. (Trust me, I’ve tried them all.) Flexibility is built into Asana’s architecture. Each “task”, or “subtask”, can be associated with a larger “project” and “department.” In addition, you can even assign recurring tasks to yourself or team, which makes life so much easier. Stop trying to remember all the things you’re supposed to do and let Asana structure your life.

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

他还表示“包括现代汽车(Hyundai Motor)和爱茉莉太平洋(AmorePacific)在内,几乎每家韩国大企业都严重依赖对华销售。”
Ever since the 1994 World Cup, the average scoring has been on a steady downward slope. In 2010 it bottomed out at 2.27, the second lowest average in World Cup history (1990 averaged just 2.20).
这也是精算师高居美国最佳工作榜首的原因之一。这是求职网站CareerCast.com最新调查结果,调查报告于周二发布。生物医学工程师排名第二位,2012年高居榜首的软件工程师如今排名第三。排名垫底的工作包括现役军人、伐木工人和报社记者。
Apple Inc.'s Chief Executive Officer Steve Jobs is shown in this combination photo of file photographs dating (top row L to R) July 2000, November 2003, September 2005, (bottom L to R) September 2006, January 2007 and September 2008. Jobs will take a medical leave of absence until the end of June because his health problems are "more complex" than he had thought, shocking investors and sending the company's shares down as much as 10 percent on January 14, 2009.

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

三月四日在好莱坞高地中心Mary J. Blige, Miguel, Gael García Bernal, Andra Day, Natalia LaFourcade, Keala Settle, Sufjan Stevens and Common将会演唱自己的原创歌曲来庆贺第90届奥斯卡。
科学家指出,这增加了暴雨和洪水的危险,因为气温升高会导致大气层里积聚更多水蒸气。

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
From the themed collection: 绿色建材满天飞 装修市场多李鬼
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

Klay Thompson added 19 points and Andrew Bogut scored 13 for the Warriors, off to the best start by an NBA team since Dallas won its first 14 games in 2002-03. Golden State needs three wins to equal the league record of 15-0, held by the 1948-49 Washington Capitols and 1993-94 Houston Rockets.
问:最后一个问题——在你的许多作品中,你总以强烈的感情质疑正义,质疑英雄主义是否道德。那么你对于成为英雄这种事是怎么看的呢?
congratulate

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
From the themed collection: 直管公房违规转租转借将被收回
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

In being named CEO, Mary Barra broke through several historical barriers in moving from GM's third-most powerful executive position to its first. Her job was made both easier by the appointment of a non-executive chairman to handle the board of directors, and more difficult by the decision to give her old job to one of her rivals. As the first product engineer to head the company in two decades, she will be deluged with suggestions about everything from air conditioning vents in new pickups to the future of brands like Buick and Chevrolet.
谈到谷歌总部,人们总会提到那些闪光点——丰富的户外运动设施、免费食品,以及其它数不清的福利。不过,下面要说的是另一项好得有些变态的福利。如果谷歌美国的某位员工在就职期间不幸身故,不管他为谷歌工作了多长时间,在之后十年里,其配偶或“伴侣”每年都可以继续领取该员工薪水的50%。
The second match will be held at the Mercedes-Benz Arena in Shanghai on Oct 8.

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

[flait]
房价尽管缓慢却持续不断地增长与近期数据走势一致,这些数据显示10月份对房地产投资有所增加,新一轮限购对录得的销售几乎没有任何负面影响。

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

It is not yet known who will look after Choupette after Lagerfeld's death.
Actor in a Mini-Series or Movie: Courtney B. Vance, “The People v. O. J. Simpson: American Crime Story”
时间:2009-11-11 编辑:vicki

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

但支撑其大国地位的经济基础正逐步下滑。
Two Chinese universities have been placed in the top 20 of this year's Times Higher Education World Reputation Rankings, according to data released last Thursday.

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

上个月,以美元计的中国出口跌幅显著超过预期,进口增幅也下滑一半以上。同时,对11月份数据的修正,抹去了原本疑似出现的人们长久期待的对外出口增长。
随着我国对稳定经济的新驱动力的投资增加,2016年我国的科技研究与试验发展经费达1.57万亿元,增长10.6%,是2014年以来最快的年增速。
正如这届美国政府中一切与贸易有关的事项一样,韩美贸易协定(Korus)的未来也不可避免地引发了激烈辩论。本届政府内部强烈反对退出该协议的是特朗普安全团队,他们认为在一场地缘政治危机期间切断与重要盟友的贸易纽带很可能不是个好主意。美国企业也不支持退出。这两股力量都可能意味着美国政府至少在短期内不会发出任何威胁。但是话又说回来,首尔方面的政治局势也不稳定。韩国新政府是否可能行使自己退出协定的权利呢?

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
From the themed collection: 北京购房市场回温 改善置业走俏
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

今年2月的时候,在格莱美颁奖典礼上,克里斯汀?韦格和玛蒂?齐格勒为希雅的歌曲《Chandelier》伴舞,希雅背对着观众(图)

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

如果这个目标真的能够实现,届时特斯拉的规模将超过林肯(Lincoln)和保时捷(Porsche)等豪车品牌的美国分支。这两个老字号豪车品牌都有更多样化的产品阵容、长期的经销商网络、成熟的营销和广告策略。特斯拉如果真的能卖出预期的数字,那么其销量的半数将来自现有的Model S轿车,其它一半则来自明年年初才会量产的Model X七座跨界车。
尽管很多人总把保时捷与纯性能车联系在一起,但近年来保时捷扩大了他们的阵容,包括帕纳梅拉,即为上图的豪华车型,除此外还有卡宴和小卡宴SUV。根据多数评论家,帕纳梅拉不仅继承了保时捷强大的性能,还满足了使用者对高端内置和联网特性的需求。

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

热门行业
According to local media, the gang, based in Nanning, the capital city of south China's Guangxi Zhuang autonomous region, was able to make up to 16,000 yuan (£1,750) profit on every tonne of the putrid meat, by injecting it with chemicals, increasing its weight by 50 per cent.

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
From the themed collection: 2016年建材行业大数记
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

purchase
Since its first release in 1995, many new versions and sequels have been created. However, fans say none could replace the breath-taking and tragic tale of the original.

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

But when he gave us his long-gestating free adaptation of Michel Faber’s novel Under the Skin, the result really was gasp-inducing: hilarious, disturbing, audacious. No less an A-lister than Scarlett Johansson plays an alien in human form who roams the streets and shopping malls of Glasgow. Perfectly genuine footage of real-life passersby is shown as the incognito Johansson impassively sizes up these earthlings for their calorific value. Then actors will step out of the crowd for their scenes with the great seducer. She takes them back to her place: a mysterious dark cavern in which, in an erotic trance, they submit to being imprisoned and farmed for their meat – and perhaps, who knows, for their very soul.
1983年的夏天,早熟的17岁少年埃利奥与家人一同在意大利北部伦巴第的17世纪乡间别墅度假。他邂逅了英俊的博士生奥利弗,后者是埃利奥父亲的实习生。那个夏天,一切都沉醉在灿烂阳光中,埃利奥和奥利弗彼此探索着欲望觉醒带来的令人晕眩的美。这个夏天将改变他们的一生。

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

Low inflation reflects weakening demand and doesn't inspire confidence about the economic shift from manufacturing to consumption, yet at the same time it should allow Beijing to enact stimulus should it seek to support the economy further .

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

The University of Pittsburgh team used stem cells made from skin to make MCPs, a special kind of cell that acts as a precursor to cardiovascular tissue. They then placed these cells on a 3-D scaffold designed to support a mouse heart. Within 20 days, the new heart began beating at 40 to 50 beats per minute.
库克的缺乏表现欲,并不总被视为一种优点。
Will impeachment proceedings begin against Donald Trump
除此之外,该杂志还指出,特朗普为竞选总统自掏腰包6600万美元,并且支付了2500万美元用于解决特朗普大学的相关诉讼。

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

谷歌的数据还显示,著名流行歌坛天后惠特尼?休斯顿今年二月份去世的消息吸引最多网民关注,风头盖过了凯特王妃。

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

根据电影监管机构数据显示,中国电影票房销售额在去年同比了增长48.7%
The third gunman, Amedy Coulibaly, who stormed a kosher supermarket on Friday,never left for such training, said Valls.
Average age: 37

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

5.You Aren't Making Enough Money to Pay Your Bills
At the same time, she said, other countries have seen their tourist numbers spike as the currencies weaken.

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

5. 范冰冰 1700万美元
Exports fell 6.6 per cent year-on-year in January to Rmb1.14tn, following a 2.3 per cent gain in December. Economists expected a gain of 3.6 per cent. It was the biggest fall in exports since an 8.9 per cent drop in July last year.

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

随着新款iPhone不断刷新自己的发售纪录,库克推出了Apple Watch和Apple Pay等产品,引领苹果进入时尚界和金融界,让这家公司再度焕发出许多人担心已和乔布斯一同逝去的创新精神。苹果今年一年市值的增长,就接近谷歌(Google)的整体市值。

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

泡沫气球是泡泡和气球的混合体。
●Van Full Of Illegals Shows Up To Vote Clinton At SIX Polling Places, Still Think Voter Fraud Is A Myth?
电池电力可能最终被证明是一种过渡性技术。最近电池成本的降低速度已经放慢了,特斯拉曾经承诺要在2017年生产出价格在35,000美元左右的Model 3。要实现这个目标,特斯拉的电池成本需要下降30%。相比之下,丰田(Toyota)最近的举动非常出人意料。它与特斯拉签订的电池供应协议即将期满,但丰田并未续约,而是准备加倍投入研发氢燃料电池。燃料电池的成本下降速度要快于普通电池。而且燃料电池的拥趸们认为,车主肯定会更喜欢充电速度相对更快的燃料电池,而不是要为充电等上好几个小时。

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

adj. 有益的,有利的
Social network Facebook Inc., e-commerce giant Amazon and toy company Lego were the top-growing brands.
Xi Jinping and other leadershave made it clear that China is willing to accept a slower growth pace if thiswill allow for a more sustainable, consumer-driven expansion of its economy.Some prognosticators are quick to conclude that China’s economy will soonsignificantly slow down, especially because China’s economy has sputteredfollowing prior instances when the nation’s leaders have effected suchfundamental economic reforms (such as in 1978 and 1993).
Two Chinese universities, University of Hong Kong and University of Macao, squeezed into the top 10 of the world's most international universities in 2016, according to a new list published by Times Higher Education on Thursday.

Graphical abstract: Length-scale dependence of protein hydration-shell density
From the themed collection: 家居物流大盘点 已形成2大阵营
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

没有什么事情能像太阳躲在月亮后面那样,把人们聚集在一起。
Its GDP increased 7.5 percent compared to last year, according to a report by 21st Century Business Herald.

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
From the themed collection: 房地产税法总体思路正在坐实
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

French authorities said in December that they have dismantled about a dozen networks that were sending people to fight in Iraq and Syria.
1. You became a LinkedIn superstar overnight。
The report also showed regions with a better-developed economy produce more cyberstars, with Beijing, Shanghai, Guangdong, Jiangsu and Zhejiang leading the rankings.

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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刘非也是汉朝皇帝汉武帝(公元前141-97在位)的同父异母兄弟。
According to exam questions and some test-takers' feedback posted online after the exam, the difficulty of the questions was moderate and hot political and social issues, such as the Long March rockets, China's foreign affairs, the Yutu lunar rover and entrepreneurial efforts by college students, were mentioned.

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